100 Examples of sentences containing the common noun "polyadenylation"

Definition

Polyadenylation is a biological process that involves the addition of a poly(A) tail, a stretch of adenine nucleotides, to the 3' end of a newly synthesized messenger RNA (mRNA) molecule. This modification is crucial for mRNA stability, export from the nucleus, and translation efficiency in eukaryotic cells.

Synonyms

• mRNA polyadenylation
• Poly(A) tail addition
• RNA polyadenylation

Antonyms

• Deadenylation (removal of the poly(A) tail)

Examples

1. Researchers found that polyadenylation is essential for the stability of mRNA in eukaryotic cells.
2. The process of polyadenylation helps regulate gene expression.
3. Scientists are studying how polyadenylation affects mRNA lifespan.
4. The efficiency of translation is enhanced by polyadenylation.
5. A mutation in the polyadenylation signal can lead to defective mRNA.
6. During transcription, polyadenylation occurs at the end of mRNA synthesis.
7. The enzyme responsible for polyadenylation is called poly(A) polymerase.
8. In some cases, polyadenylation is coupled with transcription.
9. The length of the poly(A) tail can influence the rate of polyadenylation.
10. Abnormal polyadenylation can contribute to various diseases.
11. The study of polyadenylation is crucial for understanding mRNA dynamics.
12. Alternative polyadenylation can produce different mRNA isoforms.
13. Polyadenylation plays a role in the regulation of protein synthesis.
14. The efficiency of polyadenylation can vary between different mRNAs.
15. Understanding polyadenylation mechanisms can help in gene therapy.
16. The polyadenylation process can be influenced by external factors.
17. A defective polyadenylation site can lead to truncated proteins.
18. Polyadenylation is a key step in post-transcriptional modification.
19. The role of polyadenylation in cellular responses is an active area of research.
20. Polyadenylation signals are often conserved across species.
21. The poly(A) tail aids in the nuclear export of mRNA after polyadenylation.
22. In eukaryotes, polyadenylation is a hallmark of mRNA maturation.
23. The polyadenylation process is tightly regulated during cell division.
24. Scientists have developed assays to measure polyadenylation efficiency.
25. Changes in polyadenylation patterns can indicate cellular stress.
26. The first step in polyadenylation involves recognizing the polyadenylation signal.
27. The addition of a poly(A) tail during polyadenylation protects mRNA from degradation.
28. Polyadenylation is not present in prokaryotic organisms.
29. Researchers are investigating the effects of polyadenylation on aging.
30. Inhibition of polyadenylation can lead to a decrease in protein synthesis.
31. The study of polyadenylation has implications for cancer research.
32. Polyadenylation factors can interact with other RNA-binding proteins.
33. The length of the poly(A) tail influences the stability of mRNA after polyadenylation.
34. Polyadenylation can be regulated at multiple levels within the cell.
35. The discovery of polyadenylation signals has advanced our understanding of gene regulation.
36. Alternative splicing may be linked to variations in polyadenylation.
37. The dynamics of polyadenylation can be analyzed using high-throughput sequencing.
38. Polyadenylation is crucial for the formation of functional ribosomes.
39. The role of polyadenylation in viral RNA is an emerging field of study.
40. Factors that promote polyadenylation can enhance mRNA stability.
41. The efficiency of polyadenylation can vary based on the specific gene.
42. Polyadenylation is a key regulatory mechanism in cellular signaling.
43. Disruptions in polyadenylation can lead to various genetic disorders.
44. The interaction between transcription and polyadenylation is a complex process.
45. Polyadenylation can influence the localization of mRNA within the cell.
46. The characterization of polyadenylation pathways is important for biotechnology applications.
47. The discovery of new polyadenylation factors has expanded our knowledge of RNA biology.
48. Polyadenylation can be targeted in therapeutic strategies for certain diseases.
49. The poly(A) tail added during polyadenylation plays a protective role.
50. Understanding the nuances of polyadenylation can lead to breakthroughs in medicine.
51. Cellular stress responses can modulate the rate of polyadenylation.
52. The impact of polyadenylation on gene expression is a topic of interest.
53. Polyadenylation is critical for the maturation of eukaryotic mRNAs.
54. The regulation of polyadenylation is essential for proper cellular function.
55. The study of polyadenylation has important implications for developmental biology.
56. Post-transcriptional modifications, including polyadenylation, are vital for gene regulation.
57. Polyadenylation can be influenced by the cellular environment.
58. Inhibiting polyadenylation can provide insights into mRNA dynamics.
59. The role of polyadenylation in non-coding RNAs is an area of ongoing research.
60. The relationship between polyadenylation and translation initiation is complex.
61. Polyadenylation is a necessary step for the formation of mature mRNA.
62. The mechanisms of polyadenylation are conserved across many organisms.
63. Investigating the pathways of polyadenylation can reveal new therapeutic targets.
64. The balance between synthesis and degradation is influenced by polyadenylation.
65. The discovery of alternative polyadenylation mechanisms has expanded our understanding of RNA biology.
66. The role of polyadenylation in gene silencing is being actively studied.
67. Polyadenylation can enhance the translation efficiency of specific mRNAs.
68. The addition of the poly(A) tail during polyadenylation is a crucial regulatory step.
69. Researchers are exploring the link between polyadenylation and disease progression.
70. The presence of specific elements can influence the polyadenylation process.
71. Polyadenylation is essential for the proper functioning of eukaryotic cells.
72. The dynamics of polyadenylation can vary in different stages of development.
73. The study of polyadenylation factors has implications for synthetic biology.
74. Polyadenylation can impact the stability and translation of mRNA.
75. The interaction between polyadenylation and RNA splicing is a key area of research.
76. Understanding the pathways involved in polyadenylation can lead to new insights.
77. Polyadenylation is a critical factor in mRNA turnover.
78. The role of polyadenylation in viral replication is an emerging field.
79. The mechanisms of polyadenylation have been conserved throughout evolution.
80. The study of polyadenylation can provide insights into the regulation of gene expression.
81. The efficiency of polyadenylation can be affected by RNA-binding proteins.
82. The addition of a poly(A) tail during polyadenylation enhances mRNA stability.
83. Polyadenylation can be influenced by the presence of specific proteins.
84. The role of polyadenylation in regulating mRNA localization is under investigation.
85. The complexity of polyadenylation pathways reflects the intricacies of gene regulation.
86. Understanding how polyadenylation is regulated can inform therapeutic strategies.
87. The interplay between transcription and polyadenylation is a critical aspect of gene expression.
88. Polyadenylation is an important factor in the maturation of precursor mRNA.
89. The regulation of polyadenylation is crucial for cellular homeostasis.
90. The study of polyadenylation can reveal new regulatory mechanisms in cells.
91. Polyadenylation is a fundamental process in the life cycle of eukaryotic cells.
92. The impact of polyadenylation on cellular responses to stimuli is a focus of research.
93. Polyadenylation can modulate the stability and translation of specific mRNAs.
94. The mechanisms of polyadenylation are critical for understanding RNA biology.
95. The role of polyadenylation in the regulation of gene expression continues to be explored.
96. Polyadenylation is a vital process for the production of functional mRNAs.
97. The discovery of new polyadenylation signals can expand our understanding of RNA dynamics.
98. The interplay between polyadenylation and other post-transcriptional modifications is complex.
99. Research on polyadenylation can lead to advancements in genetic engineering.
100. The study of polyadenylation is essential for unraveling the mysteries of RNA biology.